Section: Application Domains

Anesthesiology

(joint project with AP-HP Lariboisière and M3DISIM)

Two hundred million general anaesthesias are performed worldwide every year. Low blood pressure during anaesthesia is common and has been identified as a major factor in morbidity and mortality. These events require great reactivity in order to correct them as quickly as possible and impose constraints of reliability and reactivity to monitoring and treatment.

Recently, studies have demonstrated the usefulness of noradrelanine in preventing and treating intraoperative hypotension. The handling of this drug requires great vigilance with regard to the correct dosage. Currently, these drugs are administered manually by the healthcare staff in bolus and/or continuous infusion. This represents a heavy workload and suffers from a great deal of variability in order to find the right dosage for the desired effect on blood pressure.

The objective of this project is to automate the administration of noradrelanine with a closed-loop system that makes it possible to control the treatment in real time to an instantaneous blood pressure measurement.